ARBK1 Colorimetric Cell-Based ELISA

• Description:

  The ARBK1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor ARBK1 protein expression profile in cells. The kit can be used for measuring the relative amounts of ARBK1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on ARBK1.

• Synonyms:

  Beta-adrenergic receptor kinase 1; Beta-ARK-1;2.7.11.15; G-protein coupled receptor kinase 2 ; GRK2 ; ADRBK1, BARK, BARK1

• Gene Name:

  GRK2

• UniProt:

  P25098

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Expressed in peripheral blood leukocytes.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

• Molecular Weight:

  79574 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Beta-adrenergic receptor kinase 1

• Subcellular Location:

  Cytoplasm. Cell membrane.