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ARBK1 Colorimetric Cell-Based ELISA

CAT: 0519-EKC1696Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1696Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The ARBK1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor ARBK1 protein expression profile in cells. The kit can be used for measuring the relative amounts of ARBK1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on ARBK1.
Synonyms
Beta-adrenergic receptor kinase 1; Beta-ARK-1;2.7.11.15; G-protein coupled receptor kinase 2 ; GRK2 ; ADRBK1, BARK, BARK1
Gene Name
GRK2
UniProt
P25098
Reactivity
Human, Mouse, Rat
Tissue Specificity
Expressed in peripheral blood leukocytes.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
Molecular Weight
79574 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Beta-adrenergic receptor kinase 1
Subcellular Location
Cytoplasm. Cell membrane.

UniProtKB · P25098

G protein-coupled receptor kinase 2

GRK2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P25098
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GRK2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.16
Processing
—
Secondary accessions
B0ZBE1, Q13837, Q6GTT3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCell projectionCytoplasmMembraneSynapse

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

Phosphoprotein

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