ACVL1 Colorimetric Cell-Based ELISA

• Description:

  The ACVL1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor ACVL1 protein expression profile in cells. The kit can be used for measuring the relative amounts of ACVL1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on ACVL1.

• Synonyms:

  Serine/threonine-protein kinase receptor R3; SKR3;2.7.11.30; Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I; ACVRL1; ACVRLK1, ALK1

• Gene Name:

  ACVRL1

• UniProt:

  P37023

• Reactivity:

  Human, Mouse, Rat

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

• Molecular Weight:

  56124 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Serine/threonine-protein kinase receptor R3

• Subcellular Location:

  Cell membrane; Single-pass type I membrane protein.