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PTTG1 Colorimetric Cell-Based ELISA

CAT: 0519-EKC1666Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1666Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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Description
The PTTG1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor PTTG1 protein expression profile in cells. The kit can be used for measuring the relative amounts of PTTG1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on PTTG1.
Synonyms
Securin; Esp1-associated protein; Pituitary tumor-transforming gene 1 protein; Tumor-transforming protein 1; hPTTG; PTTG1; EAP1, PTTG, TUTR1
Gene Name
PTTG1
UniProt
O95997
Reactivity
Human
Tissue Specificity
Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.
Molecular Weight
22024 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Securin
Subcellular Location
Cytoplasm. Nucleus.

UniProtKB · O95997

Securin

PTTG1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95997
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTTG1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Biological process

Cell cycleCell divisionChromosome partitionDNA damageDNA repairMitosis

Cellular component

CytoplasmNucleus

Disease

Proto-oncogene

Domain

RepeatSH3-binding

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