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FOXO4 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1224Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1224Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The FOXO4 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FOXO4 protein expression profile in cells. The kit can be used for measuring the relative amounts of FOXO4 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FOXO4.
Synonyms
AFX; AFX1; Afxh; forkhead box protein O4; forkhead domain AFX1; MLLT7; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) translocated to, 7 (AFX1)
Gene Name
FOXO4
UniProt
P98177
Reactivity
Human, Mouse
Tissue Specificity
Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
Molecular Weight
53684 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Forkhead box protein O4
Subcellular Location
Cytoplasm. Nucleus. When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.

UniProtKB · P98177

Forkhead box protein O4

FOXO4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P98177
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FOXO4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B7WPJ7, O43821, Q13720, Q3KPF1, Q8TDK9
Protein keywords

Technical term

3D-structurePharmaceuticalProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Molecular function

ActivatorDevelopmental proteinDNA-binding

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Biological process

Cell cycleDifferentiationMyogenesisTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

Disease

Proto-oncogene

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