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CCR5 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1096Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1096Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The CCR5 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CCR5 protein expression profile in cells. The kit can be used for measuring the relative amounts of CCR5 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CCR5.
Synonyms
C-C CKR-5; C-C chemokine receptor type 5; CC-CKR-5; CCR-5; CD195 antigen; CHEMR13; CKR5; CMKBR5; HIV-1 fusion co-receptor; MIP-1 alpha receptor
Gene Name
CCR5
UniProt
P51681
Reactivity
Human
Tissue Specificity
Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
Molecular Weight
40524 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
C-C chemokine receptor type 5
Subcellular Location
Cell membrane; Multi-pass membrane protein.

UniProtKB · P51681

C-C chemokine receptor type 5

CCR5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P51681
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCR5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
C-C CKR-5, CC-CKR-5, CCR-5, CCR5
EC number
—
Processing
—
Secondary accessions
O14692, O14693, O14695, O14696, O14697, O14698, O14699, O14700, O14701, O14702, O14703, O14704, O14705, O14706, O14707, O14708, O15538, Q9UPA4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneMembrane

Disease

Diabetes mellitus

PTM

Disulfide bondGlycoproteinLipoproteinPalmitatePhosphoproteinSulfation

Molecular function

G protein-coupled receptorHost cell receptor for virus entryReceptorTransducer

Biological process

Host-virus interaction

Domain

TransmembraneTransmembrane helix

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