Uba2 Colorimetric Cell-Based ELISA Kit

• Description:

  The Uba2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Uba2 protein expression profile in cells. The kit can be used for measuring the relative amounts of Uba2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Uba2.

• Synonyms:

  SUMO-activating enzyme subunit 2;6.3.2.-; Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2; UBA2; SAE2, UBLE1B; HRIHFB2115

• Gene Name:

  UBA2

• UniProt:

  Q9UBT2

• Reactivity:

  Human

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

• Molecular Weight:

  71224 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  SUMO-activating enzyme subunit 2

• Subcellular Location:

  Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.