Tuberin/TSC2 Colorimetric Cell-Based ELISA Kit

• Description:

  The Tuberin/TSC2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Tuberin/TSC2 protein expression profile in cells. The kit can be used for measuring the relative amounts of Tuberin/TSC2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Tuberin/TSC2.

• Synonyms:

  Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4

• Gene Name:

  TSC2

• UniProt:

  P49815

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.

• Molecular Weight:

  200608 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Tuberin

• Subcellular Location:

  Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.