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HGS Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1272Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1272Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The HGS Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor HGS protein expression profile in cells. The kit can be used for measuring the relative amounts of HGS in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on HGS.
Synonyms
Hepatocyte growth factor-regulated tyrosine kinase substrate; HGS; IMOS-1
Gene Name
HGS
UniProt
O14964
Reactivity
Human, Mouse, Rat
Tissue Specificity
Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex) . The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
Molecular Weight
86192 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Hepatocyte growth factor-regulated tyrosine kinase substrate
Subcellular Location
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome, multivesicular body membrane; Peripheral membrane protein. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments.

UniProtKB · O14964

Hepatocyte growth factor-regulated tyrosine kinase substrate

HGS_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14964
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HGS
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q9NR36
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmEndosomeMembrane

Ligand

Metal-bindingZinc

Biological process

Protein transportTransport

Domain

Zinc-finger

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