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GluR1 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1241Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1241Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The GluR1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor GluR1 protein expression profile in cells. The kit can be used for measuring the relative amounts of GluR1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on GluR1.
Synonyms
Glutamate receptor 1; GluR-1; GluR-A; GluR-K1; Glutamate receptor ionotropic AMPA 1; AMPA-selective glutamate receptor 1; GRIA1; GLUH1; GLUR1
Gene Name
GRIA1
UniProt
P42261
Reactivity
Human, Mouse, Rat
Tissue Specificity
Widely expressed in brain.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Molecular Weight
101506 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Glutamate receptor 1
Subcellular Location
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (By similarity) .

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