GluR4 (Phospho-Ser862) Colorimetric Cell-Based ELISA Kit

• Description:

  The GluR4 (Phospho-Ser862) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor GluR4 (Phospho-Ser862) protein expression profile in cells. The kit can be used for measuring the relative amounts of GluR4 (Phospho-Ser862) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on GluR4 (Phospho-Ser862) .

• Synonyms:

  GLR4; GLUR4; GRIA4; GluR-4; GluR-D; GluR4; Glutamate receptor 4 precursor; Glutamate receptor ionotropic; AMPA 4

• Gene Name:

  GRIA4 GLUR4

• UniProt:

  P48058

• Reactivity:

  Human, Mouse, Rat

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

• Molecular Weight:

  100871 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Glutamate receptor 4

• Subcellular Location:

  Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression.