EPHB6 Colorimetric Cell-Based ELISA Kit

• Description:

  The EPHB6 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor EPHB6 protein expression profile in cells. The kit can be used for measuring the relative amounts of EPHB6 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on EPHB6.

• Synonyms:

  EPB6; Ephrin type-B receptor 6 precursor; HEP; Tyrosine-protein kinase-defective receptor EPH-6

• Gene Name:

  EPHB6

• UniProt:

  O15197

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level) . Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.

• Molecular Weight:

  110700 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Ephrin type-B receptor 6

• Subcellular Location:

  Membrane; Single-pass type I membrane protein.