Claudin 7 Colorimetric Cell-Based ELISA Kit

• Description:

  The Claudin 7 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Claudin 7 protein expression profile in cells. The kit can be used for measuring the relative amounts of Claudin 7 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Claudin 7.

• Synonyms:

  CEPTRL2; claudin 7; claudin 9; claudin-1; claudin-7; CLD7; CLDN-7; CLDN7; clostridium perfringens enterotoxin receptor-like 2; CPETRL2

• Gene Name:

  CLDN7

• UniProt:

  O95471

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Plays a major role in tight junction-specific obliteration of the intercellular space.

• Molecular Weight:

  22418 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Claudin-7

• Subcellular Location:

  Cell membrane; Multi- pass membrane protein. Basolateral cell membrane. Cell junction, tight junction. Co-localizes with EPCAM at the basolateral cell membrane and tight junction.