Claudin 10 Colorimetric Cell-Based ELISA Kit

• Description:

  The Claudin 10 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Claudin 10 protein expression profile in cells. The kit can be used for measuring the relative amounts of Claudin 10 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Claudin 10.

• Synonyms:

  Claudin-10; OSP-like protein; CLDN10

• Gene Name:

  CLDN10

• UniProt:

  P78369

• Reactivity:

  Human, Mouse

• Tissue Specificity:

  Expressed in the kidney, eccrine sweat glands and in all layers of the epidermis. In the kidney, it is detected in the thick ascending limb of Henle's loop (TAL) (PubMed:28771254, PubMed:28686597) . In the sweat glands, it is expressed in cells from secretory portions, corresponding to the clear cells (PubMed:28686597) .

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function (PubMed:19383724, PubMed:28771254, PubMed:28686597) .

• Molecular Weight:

  24488 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Claudin-10

• Subcellular Location:

  Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.