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CD88/C5aR Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1103Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1103Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The CD88/C5aR Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CD88/C5aR protein expression profile in cells. The kit can be used for measuring the relative amounts of CD88/C5aR in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CD88/C5aR.
Synonyms
C5a anaphylatoxin chemotactic receptor; C5a-R; C5AR; C5AR1; C5R1; CD88 antigen
Gene Name
C5AR1
UniProt
P21730
Reactivity
Human
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009) . The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099) . Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520) .
Molecular Weight
39336 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
C5a anaphylatoxin chemotactic receptor 1
Subcellular Location
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.

UniProtKB · P21730

C5a anaphylatoxin chemotactic receptor 1

C5AR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P21730
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
C5AR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneCytoplasmic vesicleMembrane

Biological process

Chemotaxis

PTM

Disulfide bondGlycoproteinPhosphoproteinSulfation

Molecular function

G protein-coupled receptorReceptorTransducer

Domain

TransmembraneTransmembrane helix

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