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AhR Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1019Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1019Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The AhR Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor AhR protein expression profile in cells. The kit can be used for measuring the relative amounts of AhR in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on AhR.
Synonyms
Aryl hydrocarbon receptor; Ah receptor; AhR; Class E basic helix-loop-helix protein 76; bHLHe76; BHLHE76
Gene Name
AHR
UniProt
P35869
Reactivity
Human, Mouse, Rat
Tissue Specificity
Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) . Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.
Molecular Weight
96147 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Aryl hydrocarbon receptor
Subcellular Location
Cytoplasm. Nucleus. Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.

UniProtKB · P35869

Aryl hydrocarbon receptor

AHR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35869
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AHR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Ah receptor, AhR
EC number
—
Processing
Precursor
Secondary accessions
A4D130, Q13728, Q13803, Q13804
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationADP-ribosylation

Molecular function

ActivatorDNA-bindingReceptorRepressor

Biological process

Biological rhythmsCell cycleTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

Disease

Disease variantRetinitis pigmentosa

Domain

Repeat

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