Anti-CD11c (Dendritic Cell Marker) ITGAX Monoclonal Antibody

• Background:

  CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute non-lymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

• Description:

  Boster Bio Anti-CD11c (Dendritic Cell Marker) ITGAX Monoclonal Antibody (Catalog # M00357) . Tested in Flow Cytometry, IF, Functional Assay applications. This antibody reacts with Human.

• Synonyms:

  Integrin alpha-X; CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD11c; ITGAX; CD11C

• Gene Name:

  ITGAX

• UniProt:

  P20702

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Human monocytic U937 phorbol ester-treated cells

• Clonality:

  Monoclonal

• Clone:

  Clone: Clone: HC1/1

• Tissue Specificity:

  Predominantly expressed in monocytes and granulocytes.

• Applications:

  Flow Cytometry, IF, Functional Assay

• Field of Research:

  Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Immunology, Integrins, Lymphoid, Myeloid, Signal Transduction, Stem Cells, T Lymphocytic Lineage

• Purification:

  200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.

• Concentration:

  Purified antibody with BSA and azide at 200ug/ml

• Form:

  Liquid

• Function:

  Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

• Molecular Weight:

  127829 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Fragment:

  IgG1, kappa

• Other Gene Names:

  Integrin alpha-X

• Subcellular Location:

  Cell surface