CD11c (Dendritic Cell Marker)

• Gene Name:

  [CD11c]

• NCBI Gene ID:

  3687

• Reactivity:

  Human. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.

• Other Gene Names:

  [ITGAX; ITGAX; CD11C; SLEB6; CD11C]

• Short Name:

  [CD11c]

• Other Product Names:

  [integrin alpha-X isoform 2; Integrin alpha-X; integrin alpha-X; integrin subunit alpha X; CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD_antigen: CD11c]

• NCBI GI Number:

  34452173

• NCBI Accession Number:

  NP_000878.2

• NCBI GB Accession Number:

  NM_000887.4

• Uniprot Accession Number:

  P20702