Anti-CD35 / CR1 (Follicular Dendritic Cell Marker) Monoclonal Antibody

• Background:

  Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1) /CD35. This monoclonal antibody is specific for a site in CR1 that is distal from the C3b-binding site, so that it is unable to block CR1 activity. This monoclonal antibody is highly specific to CR1 and shows no cross-reaction with CR2. The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein.Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21+/CD35+/CD1a-. This monoclonal antibody labels follicular dendritic cells and follicular dendritic cell sarcoma.

• Description:

  Boster Bio Anti-CD35 / CR1 (Follicular Dendritic Cell Marker) Monoclonal Antibody (Catalog # M01022) . Tested in Flow Cytometry, IF, IHC applications. This antibody reacts with Human, Baboon, Cynomolgus monkey, Rhesus monkey.

• Synonyms:

  Complement receptor type 1; C3b/C4b receptor; CD35; CR1; C3BR

• Gene Name:

  CR1

• UniProt:

  P17927

• Host:

  Mouse

• Reactivity:

  Human, Baboon, Cynomolgus monkey, Rhesus monkey

• Immunogen:

  Intact human monocytes

• Clonality:

  Monoclonal

• Clone:

  Clone: Clone: SPM554

• Tissue Specificity:

  Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.

• Applications:

  Flow Cytometry, IF, IHC

• Purification:

  200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.

• Concentration:

  Purified antibody with BSA and azide at 200ug/ml

• Form:

  Liquid

• Function:

  Mediates cellular binding of particles and immune complexes that have activated complement.

• Molecular Weight:

  223663 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Fragment:

  IgG1, kappa

• Other Gene Names:

  Complement receptor type 1

• Subcellular Location:

  Cell surface