CD11c (Dendritic Cell Marker)

CD11c (Dendritic Cell Marker)

• Gene Name: [CD11c]
• NCBI Gene ID: 3687
• Reactivity: Human
• Storage Conditions: Antibody with azide - store at 2 to 8°C. Non-hazardous. No MSDS required.
• Specificity: Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.
• Other Gene Names: [ITGAX; ITGAX; CD11C; SLEB6; CD11C]
• Short Name: [CD11c]
• Other Product Names: [integrin alpha-X isoform 2; Integrin alpha-X; integrin alpha-X; integrin subunit alpha X; CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD_antigen: CD11c]
• NCBI GI Number: 34452173
• NCBI Accession Number: NP_000878.2
• NCBI GB Accession Number: NM_000887.4
• Uniprot Accession Number: P20702