Human Plexin B3 ELISA Kit PicoKine®

• Background:

  Plexin-B3 is a protein that in humans is encoded by the PLXNB3 gene. Ths gene is mapped to Xq28. The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• Description:

  Human Plexin B3 ELISA Kit PicoKine® (96 Tests) . Quantitate Human PLXNB3 in cell culture supernatants, serum and plasma (heparin, EDTA) . Sensitivity: 15pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

• Synonyms:

  Plexin-B3; PLXNB3; KIAA1206; PLXN6

• Gene Name:

  Plexin B3

• UniProt:

  Q9ULL4

• Reactivity:

  Human

• Cross Reactivity:

  There is no detectable cross-reactivity with other relevant proteins.

• Immunogen:

  Expression system for standard: NS0; Immunogen sequence: H45-Q1255

• Tissue Specificity:

  Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level) . Expressed in brain, liver, pancreas and placenta, with weak expre

• Applications:

  ELISA

• Field of Research:

  Axonal Guidance Proteins, Growth and Development, Neurology Process, Neuroscience

• Sample Type:

  Cell culture supernatants, serum and plasma (heparin, EDTA) .

• Detection Range:

  93.6 pg/ml - 6,000 pg/ml

• Sensitivity:

  <15 pg/ml

• Function:

  Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca2+/Mg2+-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin

• Storage Conditions:

  Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

• Other Gene Names:

  PLXNB3

• Subcellular Location:

  Cell membrane, Single-pass type I membrane protein