Mouse IGFBP5 ELISA Kit PicoKine®

• Background:

  Insulin-like growth factor-binding protein 5 is a protein that in humans is encoded by the IGFBP5 gene. The IGFBP5 gene was mapped to chromosome 2q33-q34. The expression of IGFBP5 by stable transfection and adenovirus-mediated infection was inhibitory to growth in 2 human breast cancer cell lines. Stable expression of IGFBP5 in the breast cancer cell lines also inhibited the formation and growth of tumors following injection in athymic mice. IGFBP5 is believed a growth inhibitor and proapoptotic agent in breast cancer cells.

• Description:

  Mouse IGFBP5 ELISA Kit PicoKine® (96 Tests) . Quantitate Mouse Igfbp5 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA) . Sensitivity: 10pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

• Synonyms:

  Insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5; Igfbp5; Igfbp-5

• Gene Name:

  Insulin-like growth factor-binding protein 5

• UniProt:

  Q07079

• Reactivity:

  Mouse

• Cross Reactivity:

  There is no detectable cross-reactivity with other relevant proteins.

• Immunogen:

  Expression system for standard: NS0; Immunogen sequence: L20-E271

• Tissue Specificity:

  Most abundant in kidney, uterus and gastrocnemius muscle.

• Applications:

  ELISA

• Field of Research:

  Growth Factors/Hormones, Lipid Signaling, Signal Transduction, Signaling Pathway

• Sample Type:

  Cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA) .

• Detection Range:

  156 pg/ml - 10,000 pg/ml

• Sensitivity:

  <10 pg/ml

• Function:

  IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

• Storage Conditions:

  Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

• Other Gene Names:

  IGFBP5

• Subcellular Location:

  Secreted.

• Sequence Similarities:

  Contains 1 IGFBP N-terminal domain.

• Protein Name:

  Insulin-like growth factor-binding protein 5