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7-Methylguanine

CAT: 0804-HY-113352-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113352-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
7-Methylguanine is an orally active and competitive PARP-1 inhibitor with a Ki value of 61 μM. 7-Methylguanine is a metabolite of nucleic acids. 7-Methylguanine has anticancer activity against uterine sarcoma and colon adenocarcinoma. 7-Methylguanine is used as a probe for protein-DNA interactions[1][2][3][4][5][6].
CAS Number
578-76-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; PARP
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/7-Methylguanine.html
Purity
99.97
Solubility
1 M NaOH : ≥ 100 mg/mL|H2O : 4.72 mg/mL (ultrasonic; adjust pH to 11 with 1 M NaOH)
Smiles
O=C1NC(N)=NC2=C1N(C)C=N2
Molecular Formula
C6H7N5O
Molecular Weight
165.15
Precautions
H302, H315, H319, H335
References & Citations
[1]Lee S, et al. Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. J Am Chem Soc. 2008 Sep 3;130 (35) :11570-1.|[2]Kurgina TA, et al. Inhibitory Effects of 7-Methylguanine and Its Metabolite 8-Hydroxy-7-Methylguanine on Human Poly (ADP-Ribose) Polymerase 1. Biochemistry (Mosc) . 2022 Aug;87 (8) :823-831.|[3]Nilov D, et al. Molecular Mechanisms of PARP-1 Inhibitor 7-Methylguanine. Int J Mol Sci. 2020 Mar 20;21 (6) :2159. |[4]Kirsanov K, et al. Toxicological Properties of 7-Methylguanine, and Preliminary Data on its Anticancer Activity. Front Pharmacol. 2022 Jul 6;13:842316. |[5]Gaubatz JW, et al. Introduction, distribution, and removal of 7-methylguanine in different liver chromatin fractions of young and old mice. Mutat Res. 1997 Apr 14;375 (1) :25-35. |[6]Kirsanov K, et al. 7-Methylguanine Inhibits Colon Cancer Growth in Vivo. Acta Naturae. 2024 Apr-Jun;16 (2) :50-52.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; PARP1

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