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XM-U-14

CAT: 0804-HY-159175Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159175Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XM-U-14 is a selective PROTAC USP7 Degrader (DC50: 0.74 nM in inducing USP7 degradation in RS4;11 cell line). XM-U-14 upregulates the levels of p53 and p21. XM-U-14 also significantly inhibits acute lymphoblastic leukemia (ALL) cell growth (IC50: 0.5 nM and 8.3 nM for RS4;11 cells and Reh cells respectively). XM-U-14 induces apoptosis and cycle arrest. XM-U-14 inhibits tumor growth. (Blue: VHL ligand , Black: linker (HY-W539783) ; Pink: USP7 inhibitor (HY-159464) ).
CAS Number
3098519-83-3
UNSPSC
12352005
Target
Apoptosis; Deubiquitinase; MDM-2/p53; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xm-u-14.html
Smiles
CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)C)C4=CC(N5CCN(CC5)CC6=CC=C(C=C6)C7=C(C8=NN7C)N=CN(C8=O)CC9(CCN(CC9)C(C[C@@H](C)C%10=CC=CC=C%10)=O)O)=NO4)=O)=O
Molecular Formula
C58H69N11O7S
Molecular Weight
1064.30
References & Citations
[1]Xu M, et al. Discovery of a Highly Potent, Selective and Efficacious USP7 Degrader for the Treatment of Acute Lymphoblastic Leukemia. J Med Chem. 2024 Jul 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
USP7

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