XM-U-14

CAT: 0931-T89347-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T89347-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
DUB|||Apoptosis|||PROTACs|||MDM-2/p53
Related Pathways
DNA Damage/DNA Repair|||PROTAC|||Apoptosis|||Cell Cycle/Checkpoint|||Ubiquitination
Bioactivity
XM-U-14 is a selective PROTAC USP7 degrader that induces the degradation of USP7 in the RS4;11 cell line with a DC50 of 0.74 nM. This compound elevates the levels of p53 and p21, and significantly inhibits the growth of acute lymphoblastic leukemia (ALL) cells, with IC50 values of 0.5 nM in RS4;11 cells and 8.3 nM in Reh cells. Moreover, XM-U-14 induces apoptosis and cell cycle arrest, and effectively inhibits tumor growth.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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