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Squalene synthase-IN-2

CAT: 0804-HY-163452Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163452Size:1 Each
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Description
Squalene synthase-IN-2 (comppund isomer A- (1S, 3R) -14i) is an orally active squalene synthase inhibitor with IC50 values of 3.4, 99 nM for squalene synthase and cholesterol synthesis, respectively. Squalene synthase-IN-2 reduces plasma cholesterol and triglyceride[1].
UNSPSC
12352005
Target
Farnesyl Transferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/squalene-synthase-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H]1C[C@H](N(C(C2)=O)CCO[C@H](C3=CC=CC=C3OC)C4=CC(Cl)=CC=C4N(CC(C)(C)C)C2=O)CCC1)O
Molecular Formula
C31H39ClN2O6
Molecular Weight
571.10
References & Citations
[1]Haginoya N, et al. Discovery of Novel 11-Membered Templates as Squalene Synthase Inhibitors. J Med Chem. 2024 Mar 22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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