Squalene synthase-IN-2

• UNSPSC Description:

  Squalene synthase-IN-2 (comppund isomer A-(1S, 3R)-14i) is an orally active squalene synthase inhibitor with IC50 values of 3.4, 99 nM for squalene synthase and cholesterol synthesis, respectively. Squalene synthase-IN-2 reduces plasma cholesterol and triglyceride[1].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/squalene-synthase-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@@H]1C[C@H](N(C(C2)=O)CCO[C@H](C3=CC=CC=C3OC)C4=CC(Cl)=CC=C4N(CC(C)(C)C)C2=O)CCC1)O

• Molecular Weight:

  571.10

• References & Citations:

  [1]Haginoya N, et al. Discovery of Novel 11-Membered Templates as Squalene Synthase Inhibitors. J Med Chem. 2024 Mar 22.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported