Squalene synthase-IN-2

Squalene synthase-IN-2

• UNSPSC Description: Squalene synthase-IN-2 (comppund isomer A-(1S, 3R)-14i) is an orally active squalene synthase inhibitor with IC50 values of 3.4, 99 nM for squalene synthase and cholesterol synthesis, respectively. Squalene synthase-IN-2 reduces plasma cholesterol and triglyceride[1].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/squalene-synthase-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@@H]1C[C@H](N(C(C2)=O)CCO[C@H](C3=CC=CC=C3OC)C4=CC(Cl)=CC=C4N(CC(C)(C)C)C2=O)CCC1)O
• Molecular Weight: 571.10
• References & Citations: [1]Haginoya N, et al. Discovery of Novel 11-Membered Templates as Squalene Synthase Inhibitors. J Med Chem. 2024 Mar 22.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported