Squalene

• Description :

  Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity[1][2].

• CAS Number :

  [111-02-4]

• Product Name Alternative :

  Super Squalene; trans-Squalene; AddaVax

• UNSPSC :

  12352211

• Hazard Statement :

  H304

• Target :

  Endogenous Metabolite; Fungal; Reactive Oxygen Species (ROS)

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Cardiovascular Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Squalene.html

• Purity :

  98.0

• Solubility :

  DMSO : 16.67 mg/mL (ultrasonic) |Ethanol : 20 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C

• Molecular Formula :

  C30H50

• Molecular Weight :

  410.72

• Precautions :

  H304

• References & Citations :

  [1]Muzalevskaya EN, et al. SQUALENE: PHYSIOLOGICAL AND PHARMACOLOGICAL PROPERTIES. Eksp Klin Farmakol. 2015;78 (6) :30-6.|[2]Fernando Warleta, et al. Squalene protects against oxidative DNA damage in MCF10A human mammary epithelial cells but not in MCF7 and MDA-MB-231 human breast cancer cells. Food Chem Toxicol. 2010 Apr;48 (4) :1092-100. |[3]Clara Gabás-Rivera, et al. Dietary squalene increases high density lipoprotein-cholesterol and paraoxonase 1 and decreases oxidative stress in mice. PLoS One. 2014 Aug 12;9 (8) :e104224.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Isoform :

  Human Endogenous Metabolite; Microbial Metabolite