CB-64D

CAT: 0804-HY-120360Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-120360Size:1 Each
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Description
CB-64D is the agonist for sigma receptor 2 and sigma receptor 1 with Ki of 16.5 and 3063 nM. CB-64D induces apoptosis in cancer cell SK-N-SH[1][2].
CAS Number
[157752-20-0]
UNSPSC
12352005
Target
Apoptosis; Sigma Receptor
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cb-64d.html
Smiles
O=C1C[C@@]2(C3=CC=CC(O)=C3)CCN(C)[C@@](C2)([H])/C1=C\C4=CC=CC=C4
Molecular Formula
C22H23NO2
Molecular Weight
333.42
References & Citations
[1]Nicholson H, et al., Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity. J Pharmacol Exp Ther. 2015 Aug;354 (2) :203-12. |[2]Bowen WD, et al., CB-64D and CB-184: ligands with high sigma 2 receptor affinity and subtype selectivity. Eur J Pharmacol. 1995 May 24;278 (3) :257-60.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Sigma 1 Receptor; Sigma 2 Receptor

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