CB-64D

• Description :

  CB-64D is the agonist for sigma receptor 2 and sigma receptor 1 with Ki of 16.5 and 3063 nM. CB-64D induces apoptosis in cancer cell SK-N-SH[1][2].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Sigma Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cb-64d.html

• Smiles :

  O=C1C[C@@]2(C3=CC=CC(O)=C3)CCN(C)[C@@](C2)([H])/C1=C\C4=CC=CC=C4

• Molecular Formula :

  C22H23NO2

• Molecular Weight :

  333.42

• References & Citations :

  [1]Nicholson H, et al., Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity. J Pharmacol Exp Ther. 2015 Aug;354 (2) :203-12. |[2]Bowen WD, et al., CB-64D and CB-184: ligands with high sigma 2 receptor affinity and subtype selectivity. Eur J Pharmacol. 1995 May 24;278 (3) :257-60.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Sigma 1 Receptor; Sigma 2 Receptor

• CAS Number :

  [157752-20-0]