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CB 300919

CAT: 0804-HY-14375-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14375-01Size:5 mg
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Description
CB 300919 is a quinazoline-based antitumour agent with high activity in the CH1 human ovarian tumour xenograft. CB 300919 has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft[1]. CB 300919 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
289715-28-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NAMPT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CB-300919.html
Purity
99.10
Solubility
DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)
Smiles
CN1CCN(CC1)CC2=NC3=C(C(N2C)=O)C=C(CN(CC#C)C4=CC=C(C=C4)C(NCC5=CC=CN=C5)=O)C(Cl)=C3
Molecular Formula
C32H34ClN7O2
Molecular Weight
584.11
Precautions
H302, H315, H319, H335
References & Citations
[1]Bavetsias, V. et al. The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent. Journal of Medicinal Chemistry (2002), 45 (17), 3692-3702.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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