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CALP1

CAT: 0804-HY-P1077-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1077-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CALP1 is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity[1][2][3][4].
CAS Number
145224-99-3
UNSPSC
12352209
Target
Apoptosis; Calmodulin; mGluR; Phosphodiesterase (PDE)
Type
Peptides
Related Pathways
Apoptosis; GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/calp1.html
Purity
98.44
Solubility
DMSO : 2 mg/mL (ultrasonic)
Smiles
NCCCC[C@@H](C(O)=O)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H]([C@H](O)C)NC([C@H]([C@@H](C)CC)NC([C@H](C)NC([C@H](C(C)C)N)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C40H75N9O10
Molecular Weight
842.08
References & Citations
[1]R Houtman, et al. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J Immunol. 2001 Jan 15;166 (2) :861-7.|[2]R Ten Broeke, et al. Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 2001 Aug;15 (10) :1831-3.|[3] M K Manion, et al. A new type of Ca (2+) channel blocker that targets Ca (2+) sensors and prevents Ca (2+) -mediated apoptosis. FASEB J. 2000 Jul;14 (10) :1297-306.|[4]M Villain, et al. De novo design of peptides targeted to the EF hands of calmodulin. J Biol Chem. 2000 Jan 28;275 (4) :2676-85.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Citation 01
Int J Nanomedicine. 2025 Apr 5:20:4145-4163.|Reprod Sci. 2023 Apr;30 (4) :1281-1290.|Phytomedicine. 2025 Jul:142:156713.

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