CALP2

CAT: 0804-HY-P1076Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P1076Size:1 Each
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Description
CALP2 is a calmodulin (CaM) antagonist ((Kd of 7.9 µM) ) with high affinity for binding to the CaM EF-hand/Ca2+-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages[1][2][3][4].
CAS Number
[261969-04-4]
UNSPSC
12352209
Target
Calmodulin
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/calp2.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CCCCN)C(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H](C(C)C)C(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CCSC)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CC=CC=C3)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N
Molecular Formula
C68H104N14O13S
Molecular Weight
1357.70
References & Citations
[1]R Houtman, et al. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J Immunol. 2001 Jan 15;166 (2) :861-7.|[2]R Ten Broeke, et al. Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 2001 Aug;15 (10) :1831-3.|[3]Robert Ten Broeke, et al. Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Lab Invest. 2004 Jan;84 (1) :29-40.|[4]M Villain, et al. De novo design of peptides targeted to the EF hands of calmodulin. J Biol Chem. 2000 Jan 28;275 (4) :2676-85.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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