CALP1

CAT: 0931-MF-0045461Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0045461Size:1 mg
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CAS Number
145224-99-3
Target
CaMK|||Apoptosis|||PDE|||GluR
Related Pathways
Metabolism|||Apoptosis|||Neuroscience
Bioactivity
Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 ?M) . Shown to protect pancreatic acinar cells from gossypol induced necrosis. Inhibits VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo.
Smiles
[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)[C@@H](C)C)=O)CC(C)C)=O)[C@H](C)C)=O)[C@@H](C)O)=O)(NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)[C@H](CC)C
Molecular Formula
C40H75N9O10
Molecular Weight
842.09
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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