Anticancer agent 198

• Description :

  Anticancer agent 198 (compound 18b) is a potent anticancer agent and potential WRN protein inhibitor. Anticancer agent 198 was significantly toxic to K562 cells and WRN-overexpressing PC3 cells[1].

• CAS Number :

  [9007-83-4]

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/anticancer-agent-198.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=CC=CC(C(F)(C2=NC3=CC=CC=C3C(N(C4=CC(OC)=C(C=C4)OC)C)=N2)F)=C1

• Molecular Formula :

  C25H23F2N3O3

• Molecular Weight :

  451.47

• References & Citations :

  [1]Wang M, et al. Design, synthesis and antitumor activity of 2-substituted quinazoline-4-amine derivatives. Bioorg Med Chem. 2024 Mar 15;102:117660.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported