MW-150

• Description :

  MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].

• Product Name Alternative :

  MW01-18-150SRM

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H317, H319, H335

• Target :

  Autophagy; p38 MAPK

• Type :

  Reference compound

• Related Pathways :

  Autophagy; MAPK/ERK Pathway

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/mw-150.html

• Purity :

  99.89

• Solubility :

  DMSO : 40 mg/mL (ultrasonic)

• Smiles :

  CN1CCN(C2=NN=C(C3=CC=C4C=CC=CC4=C3)C(C5=CC=NC=C5)=C2)CC1

• Molecular Formula :

  C24H23N5

• Molecular Weight :

  381.47

• Precautions :

  H315, H317, H319, H335

• References & Citations :

  [1]Roy SM, et al. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci. 2015 Apr 15;6 (4) :666-80.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  P38α

• CAS Number :

  [1628502-91-9]