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MW-150

CAT: 0804-HY-120111-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120111-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].
CAS Number
1628502-91-9
Product Name Alternative
MW01-18-150SRM
UNSPSC
12352005
Hazard Statement
H315, H317, H319, H335
Target
Autophagy; p38 MAPK
Type
Reference compound
Related Pathways
Autophagy; MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mw-150.html
Purity
99.89
Solubility
DMSO : 40 mg/mL (ultrasonic)
Smiles
CN1CCN(C2=NN=C(C3=CC=C4C=CC=CC4=C3)C(C5=CC=NC=C5)=C2)CC1
Molecular Formula
C24H23N5
Molecular Weight
381.47
Precautions
H315, H317, H319, H335
References & Citations
[1]Roy SM, et al. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci. 2015 Apr 15;6 (4) :666-80.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
P38α

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