JSH-150

• Description :

  JSH-150 is a highly selective and potent CDK9 inhibitor with an IC50 of 1 nM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  CDK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/JSH-150.html

• Purity :

  98.66

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  COCCN[C@@H]1CC[C@@H](NC2=NC=C(Cl)C(C3=CSC(NCC4(C#N)CCOCC4)=N3)=C2)CC1

• Molecular Formula :

  C24H33ClN6O2S

• Molecular Weight :

  505.08

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Beilei Wang, et al. Discovery of 4- (((4- (5-chloro-2- (((1s,4s) -4- ((2-methoxyethyl) amino) cyclohexyl) amino) pyridin-4-yl) thiazol-2-yl) amino) methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor. Eur J Med Chem. 13 September 2018.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CDK1; CDK14; CDK16; CDK2; CDK5; CDK7; CDK9

• CAS Number :

  [2247481-21-4]