Isosorbide dinitrate-13C6

• UNSPSC Description:

  Isosorbide dinitrate-13C6 is the 13C labeled Isosorbide dinitrate[1]. Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI)[2].

• Target Antigen:

  NO Synthase

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/isosorbide-dinitrate-13c6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][13C@]([13C@@H]([13CH2]O1)O[N+]([O-])=O)(O[13CH2]2)[13C@@]1([H])[13C@H]2O[N+]([O-])=O

• Molecular Weight:

  242.09

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Wang X , et al. Intratracheal administration of isosorbide dinitrate improves pulmonary artery pressure and ventricular remodeling in a rat model of heart failure following myocardial infarction. Exp Ther Med. 2017 Aug;14(2):1399-1408.|[3]Zhao X, et al. Cardioprotective Effect of Isosorbide Dinitrate Postconditioning Against Rat Myocardial Ischemia-Reperfusion Injury In Vivo. Med Sci Monit. 2019 Mar 225:1629-1636.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported