Isosorbide dinitrate

• Description:

  Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI) [1].

• Product Name Alternative:

  ISDN

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H312, H319

• Target:

  NO Synthase

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/isosorbide-dinitrate.html

• Purity:

  99.89

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  [H][C@]12OC[C@H](O[N+]([O-])=O)[C@]1(OC[C@H]2O[N+]([O-])=O)[H]

• Molecular Formula:

  C6H8N2O8

• Molecular Weight:

  236.14

• Precautions:

  H302, H312, H319

• References & Citations:

  [1]Wang X , et al. Intratracheal administration of isosorbide dinitrate improves pulmonary artery pressure and ventricular remodeling in a rat model of heart failure following myocardial infarction. Exp Ther Med. 2017 Aug;14 (2) :1399-1408.|[2]Zhao X, et al. Cardioprotective Effect of Isosorbide Dinitrate Postconditioning Against Rat Myocardial Ischemia-Reperfusion Injury In Vivo. Med Sci Monit. 2019 Mar 2;25:1629-1636.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [87-33-2]