Isosorbide dinitrate

• Description :

  Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI) [1].

• Product Name Alternative :

  ISDN

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H312, H319

• Target :

  NO Synthase

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/isosorbide-dinitrate.html

• Purity :

  99.89

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  [H][C@]12OC[C@H](O[N+]([O-])=O)[C@]1(OC[C@H]2O[N+]([O-])=O)[H]

• Molecular Formula :

  C6H8N2O8

• Molecular Weight :

  236.14

• Precautions :

  H302, H312, H319

• References & Citations :

  [1]Wang X , et al. Intratracheal administration of isosorbide dinitrate improves pulmonary artery pressure and ventricular remodeling in a rat model of heart failure following myocardial infarction. Exp Ther Med. 2017 Aug;14 (2) :1399-1408.|[2]Zhao X, et al. Cardioprotective Effect of Isosorbide Dinitrate Postconditioning Against Rat Myocardial Ischemia-Reperfusion Injury In Vivo. Med Sci Monit. 2019 Mar 2;25:1629-1636.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [87-33-2]