Isosorbide mononitrate

Isosorbide mononitrate

• CAS Number: 16051-77-7
• UNSPSC Description: Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease[1][2][3][4].
• Target Antigen: Apoptosis; Autophagy; Endogenous Metabolite
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/Isosorbide-mononitrate.html
• Purity: 99.91
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
• Smiles: O=[N+]([O-])O[C@H]1[C@](OC[C@@H]2O)([H])[C@]2([H])OC1
• Molecular Weight: 191.139
• References & Citations: [1]Redfield MM, et al. Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction. N Engl J Med. 2015 Dec 10;373(24):2314-24. |[2]Abshagen UW. Pharmacokinetics of isosorbide mononitrate. Am J Cardiol. 1992 Nov 27;70(17):61G-66G. |[3]Pipili-Synetos E, et al. Inhibition of angiogenesis, tumour growth and metastasis by the NO-releasing vasodilators, isosorbide mononitrate and dinitrate. Br J Pharmacol. 1995 Sep;116(2):1829-34. |[4]Lv H, et al. Isosorbide mononitrate promotes angiogenesis in embryonic development of zebrafish. Genet Mol Biol. 2020 Jul 24;43(3):20190233.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched