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Isosorbide mononitrate

CAT: 0804-HY-B0642-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0642-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease[1][2][3][4].
CAS Number
16051-77-7
Product Name Alternative
Isosorbide-5-mononitrate
UNSPSC
12352005
Hazard Statement
H228, H361
Target
Apoptosis; Autophagy; Endogenous Metabolite
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Isosorbide-mononitrate.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
O=[N+]([O-])O[C@H]1[C@](OC[C@@H]2O)([H])[C@]2([H])OC1
Molecular Formula
C6H9NO6
Molecular Weight
191.14
Precautions
H228, H361
References & Citations
[1]Redfield MM, et al. Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction. N Engl J Med. 2015 Dec 10;373 (24) :2314-24. |[2]Abshagen UW. Pharmacokinetics of isosorbide mononitrate. Am J Cardiol. 1992 Nov 27;70 (17) :61G-66G. |[3]Pipili-Synetos E, et al. Inhibition of angiogenesis, tumour growth and metastasis by the NO-releasing vasodilators, isosorbide mononitrate and dinitrate. Br J Pharmacol. 1995 Sep;116 (2) :1829-34. |[4]Lv H, et al. Isosorbide mononitrate promotes angiogenesis in embryonic development of zebrafish. Genet Mol Biol. 2020 Jul 24;43 (3) :20190233.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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