Batifiban (TFA)

• Description:

  Batifiban TFA, a cyclic peptide, is an antagonist of platelet glycoprotein GPIIb/IIIa and inhibits platelet aggregation. Batifiban blocks the binding of circulating vitronectin to integrin ανβ3[1].

• UNSPSC:

  12352209

• Target:

  Glycoprotein VI

• Type:

  Peptides

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/batifiban-tfa.html

• Purity:

  99.70

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N1[C@@](C(N[C@@H](CSSCCC2=O)C(N)=O)=O)([H])CCC1)[C@@H](NC([C@@H](NC(CNC([C@@H](N2)CCCNC(N)=N)=O)=O)CC(O)=O)=O)CC3=CNC4=CC=CC=C34.OC(C(F)(F)F)=O.[x]

• Molecular Formula:

  C34H47N11O9S2.xC2HF3O2

• Molecular Weight:

  817.94 (free base)

• References & Citations:

  [1]Chen H, et al. Safety, pharmacokinetic and pharmacodynamic studies of batifiban injection following single- and multiple-dose administration to healthy Chinese subjects. J Huazhong Univ Sci Technolog Med Sci. 2009 Feb;29 (1) :12-8. [Content Brief]

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported