CDK9-IN-33

CAT: 0804-HY-162619Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-162619Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
CDK9-IN-33 (compound C35) is a potent, selective and orally active CDK9 inhibitor with IC50 values of 17.44, 160, 316.30, 1771.00, >10000 nM for CDK9, CDK7, CDK2, CDK4, CDK6 respectively. CDK9-IN-33 induces apoptosis. CDK9-IN-33 decreases the protein expression of RPB1 CTD Ser2, RPB1, MCL1. CDK9-IN-33 shows anti-tumor activity[1].
UNSPSC
12352005
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk9-in-33.html
Smiles
CC(C1=C2N=C(N=C(N2N=C1)NCC3=CC=C(C=C3)NC(CC)=O)NC4CCOCC4)C
Molecular Formula
C23H31N7O2
Molecular Weight
437.54
References & Citations
[1]Wang WJ, et al. Discovery of Orally Bioavailable and Potent CDK9 Inhibitors for Targeting Transcription Regulation in Triple-Negative Breast Cancer. J Med Chem. 2024 Jun 27;67 (12) :10035-10056.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK4; CDK6; CDK7; CDK9

Related Products

CatalogName
HY-147026-01CDK9-IN-15
HY-153426CDK9-IN-23
HY-155177CDK9-IN-27
HY-147131-01CDK9-IN-30
HY-156083CDK9-IN-28
HY-149641CDK9-IN-29
HY-150562CDK9-IN-19
HY-178039CDK9-IN-42
HY-130850-01CDK9-IN-10
HY-168515CDK9-IN-35

Alternative Products

CatalogName
T210374-01CDK9-IN-33
521355-01CDK9
MBS8529280-01CDK9 Antibody
M11131-01CDK9-IN-2
M13368-01CDK9-PROTAC
M35446-01CDK9-IN-15
310257CDK9 discontinued
MBS3614751-01CDK9-IN-10
T39354-01CDK9-IN-12
T10741CDK9-IN-1

Popular Products