SI-109

SI-109

• CAS Number: 2429877-30-3
• UNSPSC Description: SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36[1].
• Target Antigen: Ligands for Target Protein for PROTAC; STAT
• Type: Reference compound
• Related Pathways: JAK/STAT Signaling;PROTAC;Stem Cell/Wnt
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/si-109.html
• Purity: 99.91
• Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C([C@@H](NC([C@@H]1CC[C@H](CCN(C(C)=O)C[C@@H]2NC(C3=CC(C=C(C(F)(P(O)(O)=O)F)C=C4)=C4N3)=O)N1C2=O)=O)CCC(N)=O)NC(C5=CC=CC=C5)C6=CC=CC=C6
• Molecular Weight: 835.79
• References & Citations: [1]Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17.
• Shipping Conditions: Dry Ice
• Storage Conditions: -80°C, stored under nitrogen
• Clinical Information: No Development Reported