TP-030-2

TP-030-2

• CAS Number: 2095514-84-2
• UNSPSC Description: TP-030-2 is a RIPK1 inhibitor (human Ki=0.43 nM; mouse IC50=100 nM)[1][2].
• Target Antigen: RIP kinase; Ser/Thr Protease
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/tp-030-2.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C1C2=NN(CC3=CC=CC=C3)C(Br)=C2CCN1[C@@H]4C(N(C5=CC=CC=C5OC4)C)=O
• Molecular Weight: 481.34
• References & Citations: [1]Yoshikawa M, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J Med Chem. 2018 Mar 22;61(6):2384-2409.|[2]https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/TP-030-2
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported