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IBMX (GMP)

CAT: 0804-HY-12318G-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12318G-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IBMX (3-Isobutyl-1-methylxanthine) (GMP) is IBMX produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor[1][2][3][4][5].
CAS Number
28822-58-4
Product Name Alternative
3-Isobutyl-1-methylxanthine (GMP) ; Isobutylmethylxanthine (GMP)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Phosphodiesterase (PDE)
Type
GMP Small Molecules
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ibmx-gmp.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C)N(CC(C)C)C2=C(N=CN2)C1=O
Molecular Formula
C10H14N4O2
Molecular Weight
222.24
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Tio M, et al. Roles of db-cAMP, IBMX and RA in aspects of neural differentiation of cord blood derived mesenchymal-like stem cells. PLoS One. 2010 Feb 24;5 (2) :e9398.|[2]Kim SP, et al. Transcriptional activation of peroxisome proliferator-activated receptor-gamma requires activation of both protein kinase A and Akt during adipocyte differentiation. Biochem Biophys Res Commun. 2010 Aug 13;399 (1) :55-9.|[3]Lange A, et al. Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro. Lung Cancer. 2011 Nov;74 (2) :178-87.|[4]Elks ML, Manganiello VC. A role for soluble cAMP phosphodiesterases in differentiation of 3T3-L1 adipocytes. J Cell Physiol. 1985 Aug;124 (2) :191-8.|[5]Ning H, et al. Insulin growth factor signaling mediates neuron-like differentiation of adipose-tissue-derived stem cells. Differentiation. 2008 May;76 (5) :488-94.
Shipping Conditions
Blue Ice
Storage Conditions
4°C, sealed storage, away from moisture and light
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported

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