IBMX (GMP)

• Description :

  IBMX (3-Isobutyl-1-methylxanthine) (GMP) is IBMX (HY-12318) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor[1][2][3][4][5].

• Product Name Alternative :

  3-Isobutyl-1-methylxanthine (GMP) ; Isobutylmethylxanthine (GMP)

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Phosphodiesterase (PDE)

• Type :

  GMP Small Molecules

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ibmx-gmp.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N1C)N(CC(C)C)C2=C(N=CN2)C1=O

• Molecular Formula :

  C10H14N4O2

• Molecular Weight :

  222.24

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Tio M, et al. Roles of db-cAMP, IBMX and RA in aspects of neural differentiation of cord blood derived mesenchymal-like stem cells. PLoS One. 2010 Feb 24;5 (2) :e9398.|[2]Kim SP, et al. Transcriptional activation of peroxisome proliferator-activated receptor-gamma requires activation of both protein kinase A and Akt during adipocyte differentiation. Biochem Biophys Res Commun. 2010 Aug 13;399 (1) :55-9.|[3]Lange A, et al. Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro. Lung Cancer. 2011 Nov;74 (2) :178-87.|[4]Elks ML, Manganiello VC. A role for soluble cAMP phosphodiesterases in differentiation of 3T3-L1 adipocytes. J Cell Physiol. 1985 Aug;124 (2) :191-8.|[5]Ning H, et al. Insulin growth factor signaling mediates neuron-like differentiation of adipose-tissue-derived stem cells. Differentiation. 2008 May;76 (5) :488-94.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  4°C, sealed storage, away from moisture and light

• Scientific Category :

  GMP Small Molecules

• Clinical Information :

  No Development Reported

• CAS Number :

  [28822-58-4]