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Artesunate-d4

CAT: 0804-HY-N0193S1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0193S1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Artesunate-d4 is deuterium labeled Artesunate. Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1) .
CAS Number
1316753-15-7
UNSPSC
12352005
Hazard Statement
H302+H312+H332
Target
Ferroptosis; Isotope-Labeled Compounds; Parasite; STAT; Virus Protease
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; JAK/STAT Signaling; Others; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
C[C@@H]1[C@@]2([H])[C@]34[C@](O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C)([H])O[C@H]1OC(C([2H])([2H])C([2H])([2H])C(O)=O)=O
Molecular Formula
C19H24D4O8
Molecular Weight
388.45
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Ilamathi M, et al. Artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably Suppresses Hepatocellular Carcinoma. Curr Top Med Chem. 2016;16 (22) :2453-63.|[3]Lisewski AM, et al. Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate. Cell. 2014 Aug 14;158 (4) :916-928.|[4]Wang B, et al. Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51. Cancer Biol Ther. 2015;16 (10) :1548-56.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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