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Artesunate-d3

CAT: 0804-HY-N0193SSize: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0193SSize:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Artesunate-d3 is the deuterium labeled Artesunate. Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1) .
CAS Number
1316303-44-2
UNSPSC
12352005
Target
Ferroptosis; Parasite; STAT; Virus Protease
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
OC(CCC(O[C@@H]1O[C@@](O[C@](OO2)(CC[C@@]3([H])[C@@H](CC4)C)C)([H])[C@@]23[C@]4([H])[C@H]1C([2H])([2H])[2H])=O)=O
Molecular Formula
C19H25D3O8
Molecular Weight
387.44
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Ilamathi M, et al. Artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably Suppresses Hepatocellular Carcinoma. Curr Top Med Chem. 2016;16 (22) :2453-63.|[3]Lisewski AM, et al. Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate. Cell. 2014 Aug 14;158 (4) :916-928.|[4]Wang B, et al. Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51. Cancer Biol Ther. 2015;16 (10) :1548-56.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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