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Recombinant POU2F2 Antibody / OCT2

CAT: 0800-V9765SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9765SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. Oct-2 expression can be used as a marker of B-cell lineage and differentiation. Germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells show high level expression of Oct-2. Additionally, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, Hodgkin lymphoma display increased expression of Oct-2. Several studies of Oct-2 expression have shown a low level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines, whereas all mature B-cell lines have high levels of expression. In spite of scanty evidence for Oct-2 expression in T cells, it is believed that this factor participates in transcriptional regulation during T-cell activation.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P09086
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 112-297 was used as the immunogen for the recombinant POU2F2 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
OCT2/7073R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the recombinant POU2F2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This recombinant POU2F2 antibody is available for research use only.
Storage Conditions
Aliquot the recombinant POU2F2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the recombinant POU2F2 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
IHC staining of FFPE human tonsil tissue with recombinant POU2F2 antibody (clone OCT2/7073R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P09086

POU domain, class 2, transcription factor 2

PO2F2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09086
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
POU2F2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q16648, Q7M4M8, Q9BRS4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Domain

Homeobox

Biological process

TranscriptionTranscription regulation

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