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OCT-2 Antibody / POU2F2

CAT: 0800-V3913SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3913SAF-100UGSize:100 µg
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Description
Oct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. Oct-2 expression can be used as a marker of B-cell lineage and differentiation. Germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells show high level expression of Oct-2. Additionally, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, Hodgkin lymphoma display increased expression of Oct-2. Several studies of Oct-2 expression have shown a low level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines, whereas all mature B-cell lines have high levels of expression. In spite of scanty evidence for Oct-2 expression in T cells, it is believed that this factor participates in transcriptional regulation during T-cell activation.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P09086
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 112-297 from the human protein was used as the immunogen for the OCT-2 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
OCT2/2137
Applications
IHC-P
Purity
Protein G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the OCT-2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This OCT-2 antibody is available for research use only.
Storage Conditions
Store the OCT-2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the OCT-2 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
IHC testing of FFPE human lymph node with OCT-2 antibody (clone OCT2/2137) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · P09086

POU domain, class 2, transcription factor 2

PO2F2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09086
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
POU2F2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q16648, Q7M4M8, Q9BRS4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Domain

Homeobox

Biological process

TranscriptionTranscription regulation
Product Datasheet
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