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TREM2 Antibody

CAT: 0800-V9417-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9417-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), known as Nasu-Hakola disease , is a recessively inherited disease where individuals display early-onset progressive dementia and bone cysts, which leads to death. Mutations in TYROBP (DAP12), which codes for a membrane receptor component in natural-killer and myeloid cells and mutations in triggering receptor expressed on myeloid cells-2 (TREM-2), correlate well to the pathology of PLOSL. TREM-2 is a cell surface receptor on human monocyte-derived dendritic cells that forms a receptor signaling complex with DAP12 and triggers activation of the immune response in macrophages and dendritic cells (DC) . The TREM-2/DAP12 complex is a molecular promoter of upregulation of CC chemokine receptor 7, partial DC maturation, and DC survival through activation of protein tyrosine kinases and extracellular signal regulated kinase. The human chronic inflammatory TREM-2 gene maps to chromosome 6p21.1 and encodes a 230 amino acid protein.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q9NZC2
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 1-200 was used as the immunogen for the TREM2 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
TREM2/7210
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the TREM2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TREM2 antibody is available for research use only.
Storage Conditions
Aliquot the TREM2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the TREM2 antibody should be determined by the researcher.
Location
Cytoplasm, cell membrane
Image Legend
IHC staining of FFPE human small intestine with TREM2 antibody (clone TREM2/7210) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · Q9NZC2

Triggering receptor expressed on myeloid cells 2

TREM2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NZC2
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TREM2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TREM-2
EC number
—
Processing
Precursor
Secondary accessions
Q8N5H8, Q8WYN6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Alzheimer diseaseAmyloidosisDisease variantNeurodegeneration

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoprotein

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix

Ligand

Lipid-binding

Molecular function

Receptor
Product Datasheet
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