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Trem1 Antibody

CAT: 0800-R30663Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30663Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Triggering receptor expressed on myeloid cells-1, is encoded by the TREM1 gene. Expression is seen is in monocytes and neutrophils but not in lymphocytes, dendritic cells, or other cell types. The expression of Trem1 is upregulated by stimulation with lipopolysaccharide (LPS), gram-negative bacteria, and fungi. Cross-linking of TREM1 on neutrophils induces interleukin-8 (IL8) and myeloperoxidase secretion, while cross-linking on monocytes induces not only secretion of IL8 but also of monocyte chemotactic protein-1 (MCP1, or SCYA2) and tumor necrosis factor (TNF) ; MCP1 and TNF secretion could be further upregulated by LPS-mediated priming. Engagement also induces upregulation of adhesion molecules (e.g., ITGB1) and costimulatory molecules (e.g., CD40) . TREM1 is associated with DAP12 (TYROBP), a molecule frequently associated with activating receptors.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
Q9JKE2
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
Amino acids 74-90 (FTRPSEVHMGKFTLKHD-mouse) were used as the immunogen for this Trem1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the Trem1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Trem1 antibody is available for research use only.
Storage Conditions
After reconstitution, the Trem1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the Trem1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, membranous
Image Legend
Western blot testing of Trem1 antibody and Lane 1: recombinant mouse protein 10ng; 2: 5ng; 3: 2.5ng. The chimeric recombinant protein used for this test contains AA 21-202 + human Fc and is glycosylated.

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