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Recombinant CD40 Antibody

CAT: 0800-V5525-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V5525-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P25942
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant full-length human CD40 protein was used as the immunogen for the recombinant CD40 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 κ
Clone
C40/9225R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the recombinant CD40 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This recombinant CD40 antibody is available for research use only.
Storage Conditions
Aliquot the recombinant CD40 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the recombinant CD40 antibody should be determined by the researcher.
Location
Cell Surface, Secreted
Image Legend
IHC staining of FFPE human tonsil tissue with recombinant CD40 antibody (clone C40/9225R) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P25942

Tumor necrosis factor receptor superfamily member 5

TNR5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P25942
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD40
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
E1P5S9, Q53GN5, Q5JY15, Q5U007, Q7M4Q8, Q86YK5, Q9BYU0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

Disease

Disease variant

PTM

Disulfide bondGlycoprotein

Biological process

Immunity

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix
Product Datasheet
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