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Dnmt3a Antibody

CAT: 0800-F54141-0.05MLSize: 0.05 mLDry Ice: NoHazardous: No
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CAT#:0800-F54141-0.05MLSize:0.05 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:2000-1:4000
UniProt
Q9Y6K1
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human Dnmt3a was used as the immunogen for the Dnmt3a antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1823CT281.43.36
Applications
WB
Purity
Protein G purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Dnmt3a antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Dnmt3a antibody is available for research use only.
Storage Conditions
Aliquot the Dnmt3a antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Dnmt3a antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Dnmt3a antibody at 1:2000: Lane 1) human T47D, 2) CCRF-CEM, 3) Jurkat and 4) HeLa cell lysate. Predicted molecular weight: 100-130 kDa.
Product Datasheet
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